ODCs

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2 OMIM references -
2 associated genes
7 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
No signs/symptoms info

Isolated trigonocephaly

Lethal congenital contracture syndrome type 2

FGFR1	(UniProt - OMIM)		ERBB3	(UniProt - OMIM)
FREM1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FGFR1	(0.63)	ERBB3

Citations in the biomedical literature:

Isolated trigonocephaly		Lethal congenital contracture syndrome type 2
	Synonym(s): - Non-syndromic metopic craniosynostosis		Synonym(s): - LCCS2 - Multiple contracture syndrome, Israeli-Bedouin type

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Isolated trigonocephaly
	Very frequent - Autosomal dominant inheritance - Trigonocephaly Frequent - Broad nasal root - Hypotelorism - Prominent supraorbital ridge - Synophris / synophrys Occasional - Omphalocele / exomphalos
Lethal congenital contracture syndrome type 2
(no data available)